Leukemia cutis may occur within established scars and within recent areas of trauma, including hickman catheter sites, sites of burns, decubitus ulcers, 38 herpes simplex virus hsv scars, or zoster scars. Lymphocytoma cutis, or spieglerfendt sarcoid, is classed as one of the pseudolymphonas, 1 referring to inflammatory disorders in which the accumulation of lymphocytes on the skin resemble, clinically and histopathologically, cutaneous lymphomas. Aug 14, 2019 this example of lymphocytoma cutis shows a localized, erythematoustobrown, illdefined plaque. Lymphocytoma cutis of the shoulder, composed of fleshcolored or erythematous nodules in small groups. Lymphocytoma cutis involving the lower lip, contact. Pdf lymphocytoma cutis, also known as cutaneous b cell pseudolymphoma. A painless erythematous swelling of the external ear as a. The many faces of lymphocytoma cutis van vloten 2003. Lymphocytoma cutis following excision arthroplasty mehta v. Lymphocytoma cutis is a rare pseudolymphoma that has also been known as cutaneous lymphoid hyperplasia or lymphadenosis benigna cutis. Read lymphocytoma cutis involving the lower lip, contact dermatitis on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Lymphocytoma cutis is the name for a group of skin disorders defined as benign lymphoproliferative reactions that may simulate cutaneous malignant lymphomas clinically andor histologically. In 1906 jadassohn 1 presented before the ninth german dermatological congress the first case of what was later to be known as lymphocytoma cutis.
By chodynicka b flisiak i okrasinska k andrzejewska a. Clh lesions may closely resemble lymphoma both clinically and histologically. Glucocorticosteriods topical, intra lesional 540 mgml 1 ml monthly or systemic 604020 mg 5 days each tapered, hydroxychloroquine 200 mg twice daily, and minocycline 50100 mg twice daily have been used in the past with varied success 4. Borrelial lc occurs most commonly in areas endemic for ixodes ricinus tick in europe, and it is rare in north america. Covering all aspects of skin disease from basic science through pathology and epidemiology to clinical practice, the text is recognized for its unparalleled coverage of diagnosis. A few weeks later, two erythematous macules, each 710 cm in diameter, had developed over his left chest and within a month both lesions disappeared untreated. It clinically presents as skincolored to darkred papules, nodules, or infiltrative.
Typically, the lesions are small, superficial, translucent, firm, nontender, pinkishred. These range from skin coloured to redbrown or redpurple in colour, and occasionally have a scale or crust on the surface. Lymphocytoma cutis following excision arthroplasty. Lymphocytoma cutis, also known as cutaneous b cell pseudolymphoma, represents a. The presenting red or purple papule, nodule, or plaque commonly arises on the face. The areas of predilection are the ear lobe, nipple and areola, and scrotal area. Lymphoma or lymphocytoma cutis dermatology medhelp. The clinical differential diagnosis in each variety is difficult and includes numerous infiltrative disorders. In the literature one may find a large number of confusing names for these conditions, such as sarcoidosis of spiegler and fend, lymphocytoma benigna cutis. Cutaneous presentation of orbital follicular lymphoma. A 34yearold man presented to the outpatient dermatology clinic with 3 groups of mildly pruritic, erythematous papules and plaques on the right posterior shoulder, left midback, and left serratus anterior muscle. A 75 year old woman presented to the dermatologist with a 67 month history of lumps on the right and left ears. Histologically, there is an intense polyclonal lymphocytic.
A diagnostic dilemma lymphocytoma cutis lc is one of the most common types of cutaneous b cell pseudolymphoma. A panel of monoclonal antibodies leucocyte common antigen cd45, ln. In areas endemic for the tick, ixodes ricinus, this disease is more common. We detected zinc through scanning electron microscopy from the specimen of case 1 and gold and titanium through transmission electron microscopy from case 2. We report a case of lymphocytoma cutis with conjunctival lesions. Cutaneous lymphoid hyperplasia lymphocytoma cutis, lymphadenosis benigna cutis, cutaneous lymphoplasia, pseudolymphoma of spieglerfendt. Rooks textbook of dermatology is the most comprehensive work of reference available to the dermatologist. This photograph of lymphocytoma cutis caused by an arthropod bite shows an erythematous scaling patch of the scalp with localized secondary alopecia. In europe, cutaneous lymphoid hyperplasia lymphocytoma cutis has been associated with borrelia infection and is said to be the most common cause in endemic areas. Jan 26, 2011 i did a literature search for either uvb or puva being used for lymphocytoma cutis and there is not a single article or case report in the world. The disease is rarely seen in india and may cause diagnostic difficulties for dermatologist residing in parts of the world that are not endemic for lyme disease. Borrelial lymphocytoma bl is a rare skin manifestation of european lyme borreliosis lb.
Cutaneous lymphoid hyperplasia refers to a groups of benign cutaneous disorders characterized by collections of lymphocytes, macrophages, and dendritic cells in the skin. Cutaneous bcell pseudolymphoma bpsl is often also referred as lymphocytoma cutis or cutaneous lymphoid hyperplasia. We present a case of a 54yearold woman who spontaneously developed lesions of unknown cause consistent with clh. It is a process that simulates a cutaneous lymphoma blood cell cancer developing in the skin, but it behaves in a harmless manner. Atypical location of lymphocytoma cutis in a child atypical location of lymphocytoma cutis in a child amschler, katharina.
Cutaneous pseudolymphoma refers to a heterogenous group of benign reactive tcell or bcell lymphoproliferative processes of diverse causes that simulate cutaneous lymphomas clinically and histologically. We report two cases of lymphocytoma cutis caused by pierced earrings, with the results of patch tests and x. Clinically, it is characterized by a bluered plaque or nodule of 15 cm in. Department of dermatology, venereology and allergology. The content on this site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. When lymphocytoma was the sole manifestation of lyme borreliosis or associated with erythema migrans only patients were treated orally with doxycycline. Nov 28, 2012 lymphocytoma cutis, or spieglerfendt sarcoid, is classed as one of the pseudolymphonas, 1 referring to inflammatory disorders in which the accumulation of lymphocytes on the skin resemble, clinically and histopathologically, cutaneous lymphomas.
Atypical location of lymphocytoma cutis in a child, pediatric. Treatment results in 65 patients with borrelial lymphocytoma 22 on the ear lobe and 43 on the breast, registered at the department of infectious diseases, university medical centre ljubljana, from january 1986 to march 1995, are presented. Immunohistochemical differential diagnosis between. Over time a number of other conditions have been added to this category, as reports of conditions mimicking a lymphoma have been described. We report a patient with follicular lymphoma of the orbit who presented initially with cutaneous lesions clinically resembling lymphocytoma cutis which subsequently proved to be metastasis from the orbit. Entzundliche veranderungen des kindlichen genitales stellen haufig eine diagnostische herausforderung dar. Lymphocytoma cutis lc is considered as the stereotypical example of the cutaneous b. Pdf borrelia lymphocytoma lymphadenosis benigna cutis. Lymphocytoma cutis is the name for a group of skin disorders defined as benign lymphoproliferative reactions that may simulate cutaneous. Lymphocytoma cutis is a subtype of cutaneous pseudolymphoma involving the face, chest, and upper extremities. Benign lymphocytoma cutis definition of benign lymphocytoma.
Lymphomatoid tissue reactions mimicking cutaneous t and b cell lymphoma chapter 5. Depending on aetiology, cbpl is also known as cutaneous lymphoid hyperplasia, lymphocytoma cutis, sarcomatosis cutis of spieglerfendt and bafverstedt syndrome. A diagnostic dilemma rajat kandhari 1, sanjiv kandhari 2, sudhir jain 3 1 department of dermatology and sexually transmitted disease, safdarjung hospital, new delhi, india 2 consultant dermatologist, 11 munirka marg, vasant vihar, new delhi, india 3 consultant pathologist, oncquest laboratories, 3 factory road. Cutaneous lymphoid hyperplasia with nodular pattern, a condition of the skin characterized by a solitary or localized cluster of asymptomatic erythematous to violaceous papules or nodules cutaneous lymphoid. Borreliaassociated bcell pseudolymphoma lymphocytoma cutis and lymphadenosis cutis benigna often are synonymously used.
The presentation and behaviour depend on which the particular subtype. Lymphocytoma cutis following excision arthroplasty mehta. It was reported as a case of pseudoleukemic infiltration of the skin. It is a benign condition that may be mistaken both histologically and clinically for malignant. About 1 items found relating to lymphocytoma benign cutis. Lymphocytoma cutis presents as soft, doughy or firm nodules lumps. Lymphocytoma cutis lc is one of the most common types of cutaneous b cell pseudolymphoma.
The patient reported having similar episodes dating back to his early 20s. Lymphocytoma definition of lymphocytoma by medical dictionary. The diagnosis is based on histology, the clinical context history of tick bite and localization at predilection site, serologic findings, andor detection of borrelia burgdorferi species dna in the tissue by pcr. Grenz zone definition of grenz zone by medical dictionary. The term lymphocytoma cutis stands for a highly heterogeneous group of reactive lymphoid proliferations in the skin. Lymphocytoma cutis is a rare cutaneous eruption that may possess clinical and histologic features resembling malignant lymphoma. In those instances, the lesions presented without an inciting incident, became more pronounced, and. A series of five patients successfully treated with cryosurgery avery s. Lymphadenosis benigna cutis resulting from borrelia. It appears as a small skin induration that slowly enlarges to a solitary bluishred nodule or plaque with a diameter up to a few centimeters and is predominantly located on the ear lobe in children and the breast in adults figure 1a and 1b. Lymphocytoma cutis presents as asymptomatic nodules and plaques most commonly on the face, but any site may be involved.
Myelodysplasia cutis versus leukaemia cutis 2 20 patients with 24 patients with myelodysplasia cutis leukemia cutis % % clinical criteria 1 plaques 2 fever andor arthralgia 3 nodules 4 annular pattern pvalue 96 71 12. Concise summary of the heteregenous clinical manifestations of skin pseudolymphomas, including clh lymphocytoma cutis. No fever, malaise, or other systemic symptoms were reported. Lymphocytoma cutis primary care dermatology society uk. Sep 01, 20 lyme borreliosis is a common infectious disease that can affect myocardial muscle or the central nervous system if not treated at an early stage. This rare cutaneous manifestation of lyme borrelioses appears in the early phase of infection, between 2 days and 6 months after a tick bite. Borrelial lymphocytoma lymphadenosis benigna cutis. Major advances have been made in the histologic classification. Clinically it is manifested as asymptomatic, indolent, nodular lesions of different sizes varying between 2 and 5 cm, usually solitary, mainly on exposed area of the. Lymphocytoma cutis cutaneous lymphoid hyperplasia, cutaneous bcell pseudolymphoma, spieglerfendt sarcoid is an entity encompassing a spectrum of benign bcell lymphoproliferative diseases that share clinical and histopathologic features. Vandana mehta 1, c balachandran 2, sunaina hameed 2 1 department of dermatology, dr hassan al abdulla medical centre, karnataka,india 2 department of skin and std, kmc manipal, karnataka, india. This example of lymphocytoma cutis shows a localized, erythematoustobrown, illdefined plaque. This is largely based on the histological microscopic appearance.
Cutaneous lymphoid hyperplasiaalso known as lymphocytoma cutis and pseudolymphomais a benign skin disorder that is characterized histologically by a dense collection of lymphocytes within the dermis. Various stimuli can induce lymphocytoma cutis, but in most cases the cause is not known. Histologic and immunohistochemical analysis revealed the correct diagnosis. Lymphocytoma definition at, a free online dictionary with pronunciation, synonyms and translation. Photodynamic therapy however has been tried for lymphocytoma cutis. Pdf we describe a clinical case involving a 62yearold white male, diagnosed with lymphocytoma cutis spieglerfendt sarcoid in the cephalic. Localized lymphocytoma cutis, the most common form, may occur in both children and adults and has a short course. Although multiple lesions may erupt, solitary nodules ranging from less than 1 cm to several centimeters in diameter are the rule fig. Leinweber, b, mullegger, r, chott, kerl, h, cerroni, l. Atypical location of lymphocytoma cutis in a child. Cutaneous pseudolymphomas are a group of benign reactive t or b cell lymphoproliferative processes of diverse etiology that simulate. Grouped erythematous papules and plaques on the trunk. Lymphocytoma cutis skin lymphoma americorps health blog. Cutaneous pseudolymphoma cpl is a reactive polyclonal t or bcell lymphoproliferative.
A few cases of cutis laxa following febrile illness have been reported from india 4,5. Less than 1% of patients with stage 2 lyme disease, almost all of them european, develop borrelia lymphocytoma, described as a small, bluishred nodule or. Lymphocytoma cutis with conjunctival lesions british. Search icd10 code lookup find diagnosis codes icd10cm and procedure codes icd10pcs by disease, condition or icd10 code. An 8 year old boy had been bitten by a tick in his left axilla five months ago. These include borrelia burgdorferi associated lesions, 1 postzoster scar reactions, 2 trauma, 3, 4 and those of unknown aetiology. Pseudolymphoma, cutaneous lymphoid hyperplasia, reactive lymphoid hyperplasia, lymphocytoma cutis. Pseudolymphoma is characterized by a benign infiltration of lymphoid cells or histiocytes which microscopically resembles a malignant lymphoma. Two cases of disseminated lymphocytoma cutis are reported. Cutaneous involvement from primary orbital lymphoma is uncommon. Editor,lymphocytoma cutis is a benign lymphoid hyperplasia which typically occurs over the head and neck. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease. Here we report a unique case of an atypical location of lymphocytoma cutis in a 3.
The disease is rarely seen in india and may cause diagnostic difficulties for dermatologist residing in parts of the world that are not. Pseudolymphomas may arise in response to a wide variety of foreign antigens, but most are idiopathic. In 1922, when discussing bibersteins2 case, jadassohn commented that his original. Borrelial lc occurs most commonly in areas endemic for.
There may be isolated lesions or regionalareas of localization. The original description applied only to lymphocytoma cutis. Lymphocytoma cutis, also known as cutaneous b cell pseudolymphoma, represents a spectrum of disease that shares similar clinical and histological features and simulates cutaneous lymphoma clinically and histologically. Lymphocytoma cutis, or lymphadenosis benigna cutis labc, has also been considered a cutaneous from the departments of pathology a and dermatology, b womens college hospital, university of toronto, and the arbovirus refer ence service, department of microbiology, university of toronto5 reprint requests. Borrelial lymphocytoma cutis successfully treated with intralesional interferonalpha2a. This is the first report to demonstrate the presence of metal fragments in. The many faces of lymphocytoma cutis van vloten 2003 journal. Pdf on aug 1, 2002, s gissler and others published borrelia lymphocytoma lymphadenosis benigna cutis find, read and cite all the research you need on researchgate. Lymphocytoma medical definition merriamwebster medical. Editor, lymphocytoma cutis is a benign lymphoid hyperplasia which typically occurs over the head and neck. Lymphocytoma cutis treated with topical tacrolimus. Plasma cell leukemia cutis has been reported to occur in recent puncture sites. Clinically it is manifested as asymptomatic, indolent, nodular lesions of different sizes varying between 2 and 5 cm, usually solitary, mainly on exposed area of the body like. In 1922, when discussing bibersteins 2 case, jadassohn commented that his original patient was still living, that the skin lesions were unchanged and that no.
It can be induced by various antigenic stimuli including arthropod bites, vaccination, and drugs among others. Clinical findings the localized form of bpsl presents with a solitary nodule, measuring up to 4 cm in most of the cases. Lymphocytoma cutis is a rare, chronic, benign cutaneous bcell lymphoproliferative condition usually presenting with redpurple papules, nodules or plaques predominantly on the head and neck. A group of disorders having a benign course but exhibiting clinical and histological features suggestive of malignant lymphoma. In 1906 jadassohn1 presented before the ninth german dermatological congress the first case of what was later to be known as lymphocytoma cutis.
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